Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients.

ABSTRACT: The E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. The present study involves whole-genome-wide comparison and phylogenetic analysis of pks harboring E. coli isolates to gain insight into the distribution and evolution of these organisms. Fifteen E. coli strains isolated from patients with ulcerative colitis (UC) were sequenced, 13 of which harbored pks islands. In addition, 2,654 genomes from the public database were also screened for pks harboring E. coli genomes, 158 of which were pks-positive (pks⁺) isolates. Whole-genome-wide comparison and phylogenetic analysis revealed that 171 (158 + 13) pks⁺

SUBMITTER: Lv C 

PROVIDER: S-EPMC11707995 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature