Characterization of Shigella flexneri serotype 6 strains from geographically diverse low- and middle-income countries.

ABSTRACT: Shigella flexneri serotype 6 (Sf6) is one of the most common serotypes recovered from surveillance studies of moderate to severe diarrhea. Despite the clinical significance of Sf6, this serotype is understudied. In this work, we have performed both serotype-specific genomic and phenotypic comparisons of Sf6 isolates to one another and non-S. flexneri serotypes. Comparative genomic analyses identified significant nucleotide homology between Sf6 strains (n = 325), despite a broad range of collection timeframes and geographic locations. We identified Sf6 specific factors, including a potential novel Shigella virulence factor (type II secretion system). Additionally, we identified established Shigella virulence genes

SUBMITTER: Gabor CE 

PROVIDER: S-EPMC11708030 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature