Transcription factor-dependent regulatory networks of sexual reproduction in Fusarium graminearum.

ABSTRACT: Transcription factors (TFs) involved in sexual reproduction in filamentous fungi have been characterized. However, we have little understanding of how these TFs synergize within regulatory networks resulting in sexual development. We investigated 13 TFs in Fusarium graminearum, whose knockouts exhibited abortive or arrested phenotypes during sexual development to elucidate the transcriptional regulatory cascade underlying the development of the sexual fruiting bodies. A Bayesian network of the TFs was inferred based on transcriptomic data from key stages of sexual development. We evaluated in silico knockout impacts to the networks of the developmental phenotypes among the TFs and guided knockout transcriptomics experiments to properly assess regulatory roles of genes with sa

SUBMITTER: Kim W 

PROVIDER: S-EPMC11708053 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature