Causality between insulin use and malignant tumors of the digestive system: a two-sample mendelian randomized study.

ABSTRACT:

Background

Existing cohort studies show no association between insulin use and cancers of the digestive system, while numerous meta-analyses suggest that insulin use increases the risk of digestive system tumours. This study uses two-sample Mendelian randomization (MR) to further investigate the causal relationship between the two.

Methods

We selected single nucleotide polymorphisms (SNPs) strongly associated with insulin use as instrumental variables and used aggregated statistics on digestive system neoplasms as the outcome event. The primary method of analysis was inverse variance weighting (IVW), supplemented by weighted median, MR-Egger regression, weighted mode and simple mode methods. The reliability of the study was assessed by heterogeneity testing, pleiotropy analy

SUBMITTER: Chen D 

PROVIDER: S-EPMC11708065 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature