Potentially actionable molecular alterations in particular related to poor oncologic outcomes in salivary gland carcinomas.

ABSTRACT:

Aim

The study was designed to evaluate molecular alterations, relevant to the prognosis and personalized therapy of salivary gland cancers (SGCs).

Materials and methods

DNA was extracted from archival tissue of 40 patients with various SGCs subtypes. A targeted next-generation sequencing (NGS) panel was used for the identification of small-scale mutations, focal and chromosomal arm-level copy number changes. The final analysis included selected genes with potential actionable aberrations for targeted therapies and outcome predictions in 37 tumours' samples.

Results

The follow-up of the SGCs study cohort revealed disease recurrence or metastasis in 19 patients and indicated poor individual outcomes. The mean disease-free survival (DFS) within the poor outcome group was

SUBMITTER: Pikul J 

PROVIDER: S-EPMC11708168 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature