Marginal interaction test for detecting interactions between genetic marker sets and environment in genome-wide studies.

ABSTRACT: As human complex diseases are influenced by the interaction between genetics and the environment, identifying gene-environment interactions (G×E) is crucial for understanding disease mechanisms and predicting risk. Developing robust quantitative tools for G×E analysis can enhance the study of complex diseases. However, many existing methods that explore G×E focus on the interplay between an environmental factor and genetic variants, exclusively for common or rare variants. In this study, we developed MAGEIT_RAN and MAGEIT_FIX to identify interactions between an environmental factor and a set of genetic markers, including both rare and common variants, based on the MinQue for Summary statistics. The genetic main effects in MAGEIT_RAN and MAGEIT_FIX are modeled as random and fixed effects, r

SUBMITTER: Shen L 

PROVIDER: S-EPMC11708225 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature