The cardiac blood transcriptome predicts de novo onset of atrial fibrillation in heart failure.

ABSTRACT: Heart failure (HF) increases the risk of developing atrial fibrillation (AF), leading to increased morbidity and mortality. Therefore, better prediction of this risk may improve treatment strategies. Although several predictors based on clinical data have been developed, the establishment of a transcriptome-based predictor of AF incidence in HF has proven to be more problematic. We hypothesized that the transcriptome profile of coronary sinus blood samples of HF patients is associated with AF incidence. We therefore enrolled 192 HF patients who were selected for biventricular cardioverter defibrillator implantation. Both coronary sinus and peripheral blood samples were obtained during the procedure. Patients were followed-up during two years and AF occurrence was based on interrogation of

SUBMITTER: Lamirault G 

PROVIDER: S-EPMC11708251 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature