Determinants of growth differentiation factor 15 plasma levels in outpatients with peripheral arterial disease.

ABSTRACT:

Background

Growth differentiation factor 15 (GDF-15) is a robust prognostic biomarker in patients with cardiovascular (CV) disease, and a better understanding of its clinical determinants is desirable. We aimed to study the associations between GDF-15 levels and traditional CV risk factors, indicators of atherosclerotic burden, and cardiac geometry and dysfunction in outpatients with peripheral arterial disease (PAD).

Methods

An explorative cross-sectional study (Study of Atherosclerosis in Vastmanland, Västerås, Sweden) included 439 outpatients with carotid or lower extremity PAD. The mean age was 70 years (standard deviation [SD] 7), and 59% of the patients were men. Plasma levels of GDF-15 were obtained along with potential determinants, including medical history,

SUBMITTER: Skau E 

PROVIDER: S-EPMC11708457 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature