Validity of Customized Branched Tissue Engineered Vascular Graft in a Porcine Model.

ABSTRACT:

Background

Patient-specific, 3-dimensional printed, tissue engineered vascular grafts (3DTEVGs) are manufactured to optimize hemodynamic performance and to accommodate growth. We evaluate growth outcomes of 3DTEVGs compared with standard grafts for pulmonary artery reconstruction in porcine models.

Methods

Magnetic resonance imaging (MRI) with 4-dimensional flow data was acquired in porcine models (n = 8). 3DTEVGs guided in design by computational flow dynamics were implanted (n = 4), with polytetrafluorethylene grafts used as controls (n = 4). Postoperative MRI and histologic features of explanted grafts were evaluated after 10 weeks.

Results

All pigs survived, with evidence of patent grafts on postoperative MRI. Graft inner diameter changes were 0.47 ± 2.31 mm in 3D

SUBMITTER: Hayashi H 

PROVIDER: S-EPMC11708597 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature