Genomic and Serological Rheumatoid Arthritis Biomarkers, <i>MUC5B</i> Promoter Variant, and Interstitial Lung Abnormalities.

ABSTRACT: Rationale: Rheumatoid arthritis (RA) has been implicated in interstitial lung disease, as the majority of studies have comprised patients with known RA. However, it remains unclear whether an underlying risk for RA in combination with genetic risk for pulmonary fibrosis is associated with radiological markers of early lung injury and fibrosis in broader population samples. Objective: We sought to determine whether genetic and serological biomarkers of RA risk in combination with the MUC5B (rs35705950) risk allele (T) are associated with interstitial lung abnormalities (ILAs) on computed tomography scans. Methods: Associations of RA-risk HLA-DRB1 alleles (*04:01, *04:08, *04:05, *04:04, and *10:01) and serum RA autoantibo

SUBMITTER: Kim JS 

PROVIDER: S-EPMC11708761 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature