Investigating the causal relationships between attention-deficit/hyperactivity disorder and autoimmune diseases: Evidence from Mendelian randomization study.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) and autoimmune diseases have been found to be correlated in the observational studies, but the causal relationships have not been fully investigated. Two-sample Mendelian randomization (MR) analysis was used to explore the causal relationships between ADHD and 8 autoimmune disorders (systemic lupus erythematosus, Crohn disease, ulcerative colitis, type 1 diabetes, rheumatoid arthritis, psoriasis, ankylosing spondylitis [AS], and multiple sclerosis) with the publicly available genome-wide association study data in the European populations. Inverse-variance weighted (IVW), weighted median, and MR-Egger were used to estimate the causal effects. Extensive sensitivity analyses were employed to validate the 3 assumptions of MR and robustness of the

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11709194 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature