Effect of a single rectal fecal microbiota transplantation on clinical severity and fecal microbial communities in dogs with chronic inflammatory enteropathy.

ABSTRACT:

Background

Fecal microbiota transplantation (FMT) has been advocated as a treatment for chronic enteropathy (CE) in dogs. However, so far only short-term clinical effects have been reported whereas the effect on the microbiota remains unexplored.

Hypothesis/objectives

Assess if a single FMT enema can lead to clinical improvement in dogs with CE when accompanied by presumed favorable microbiota changes. The effect of glycerol as a cryopreservative when storing FMT preparations also was assessed.

Animals

Seven dogs with CE that received FMTs from 2 healthy donor dogs.

Materials and methods

Six dogs received a single FMT, 1 dog received 3 consecutive FMTs. Canine chronic enteropathy clinical activity index (CCECAI) and fecal samples were obtained before (Day 0), a

SUBMITTER: Perez-Accino J 

PROVIDER: S-EPMC11710856 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature