Exploring novel drug targets for erectile dysfunction through plasma proteome with genome.

ABSTRACT:

Background

Currently, the treatment and prevention of erectile dysfunction (ED) remain highly challenging.

Aim

This study conducted a systematic druggable genome-wide Mendelian randomization (MR) analysis to identify potential therapeutic targets for ED.

Methods

A proteome-wide MR approach was employed to investigate the causal effects of plasma proteins on ED. Subsequently, summary data-based MR (SMR) analysis was performed to identify potential drug targets for ED. Enrichment analysis and protein-protein interaction (PPI) networks revealed the functional characteristics and biological relevance of these potential therapeutic targets. Drug prediction and molecular docking studies were conducted to validate the pharmacological activity of these identified targets. Fin

SUBMITTER: Qiu Z 

PROVIDER: S-EPMC11710913 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature