The association of SUR1 polymorphisms with acute infarct size: The MRI-GENIE study.

ABSTRACT:

Background

The sulfonylurea receptor 1 (SUR1) is a known mediator of cerebral edema in large ischemic strokes, however, genetically induced response variability has yet to be evaluated. SUR1, encoded by the ABCC8 gene, is an ion channel regulator in ischemia-induced cerebral edema. Previous studies in severe traumatic brain injury demonstrated four tag single nucleotide polymorphisms (SNPs) of the ABCC8 gene to be associated with cerebral edema and functional outcome. We hypothesized that these four SNPs would also be associated with acute infarct size and functional outcome in non-lacunar ischemic stroke.

Methods

Using 2,205 MRI-GENetics Interface Exploration (MRI-GENIE) study subjects with acute non-lacunar ischemic strokes, we evaluated the association between the 4 ABCC8

SUBMITTER: Deng A 

PROVIDER: S-EPMC11710974 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature