Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans.

ABSTRACT:

Background

Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset and progression. Although previous studies have suggested that certain diets may reduce the incidence of AD, the underlying mechanisms remain unclear.

Method

In this post-hoc analysis of a randomized crossover study of 20 elderly adults, we investigated the effects of a modified Mediterranean ketogenic diet (MMKD) on the plasma lipidome in the context of AD biomarkers, analyzing 784 lipid species across 47 classes using a targeted lipidomics platform.

Results

Here we identified substantial changes in response to MMKD intervention, aside from metabolic changes associated with a ketogenic diet, we identifie

SUBMITTER: Neth BJ 

PROVIDER: S-EPMC11711287 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature