Associations of KRAS Mutations and Clinical Characteristics of Colorectal Cancer Patients in Indonesia.

ABSTRACT:

Background

Colorectal cancer (CRC) remains a major burden worldwide, ranking third and second in incidence and mortality respectively. Detection of biomarkers including KRAS mutations can help predict prognosis and response to therapy in CRC, thus this study evaluated the frequency of KRAS mutations among Indonesian patients and their associations with clinicopathologic characteristics.

Methods

Fifty-three CRC samples were collected from January to September 2022 in the Department of Surgery, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. KRAS mutations were analyzed using PCR followed by Sanger sequencing. Associations between KRAS mutations were evaluated using binary logistic regression analysis.

Result

KRAS mutations were detected in 52.8% of patients (n=

SUBMITTER: Rudiman R 

PROVIDER: S-EPMC11711353 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature