Identifying preeclampsia-associated key module and hub genes via weighted gene co-expression network analysis.

ABSTRACT: Preeclampsia (PE) is a common hypertensive disease in women with pregnancy. With the development of bioinformatics, WGCNA was used to explore specific biomarkers to provide therapy targets efficiently. All samples were obtained from gene expression omnibus (GEO), then we used a package named "WGCNA" to construct a scale-free co-expression network and modules related to PE. Next, the search tool for the retrieval of interacting genes database (STRING) was adopted to structure the protein-protein interaction (PPI) of genes in the hub module. Furthermore, the MCODE plug-in was applied to discern hub clusters of the PPI network. We also utilized clusterprofiler to execute the functional analysis. Finally, hub genes were selected via Venn Plot and confirmed by quantitative real-time polymerase

SUBMITTER: Li J 

PROVIDER: S-EPMC11711461 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature