PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways.

ABSTRACT: Post-translational modifications (PTMs) play pivotal roles in regulating cellular signaling, fine-tuning protein function, and orchestrating complex biological processes. Despite their importance, the lack of comprehensive tools for studying PTMs from a pathway-centric perspective has limited our ability to understand how PTMs modulate cellular pathways on a molecular level. Here, we present PTMNavigator, a tool integrated into the ProteomicsDB platform that offers an interactive interface for researchers to overlay experimental PTM data with pathway diagrams. PTMNavigator provides ~3000 canonical pathways from manually curated databases, enabling users to modify and create custom diagrams tailored to their data. Additionally, PTMNavigator automatically runs kinase and pathway enrichment a

SUBMITTER: Muller J 

PROVIDER: S-EPMC11711753 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature