Enhancement of photoinduced reactive oxygen species generation in open-cage fullerenes.

ABSTRACT: Photodynamic therapy is an important tool in modern medicine due to its effectiveness, safety, and the ability to provide targeted treatment for a range of diseases. Photodynamic therapy utilizes photosensitizers to generate reactive oxygen species (ROS). Fullerenes can be used as photosensitizers to produce ROS in high quantum yields. Open-cage fullerenes are a subclass of fullerenes characterized by a partially open structure, with one or more openings or apertures. The promising electrochemical properties of open-cage fullerenes motivated us to investigate their use for DNA-cleavage and ROS generation under visible light irradiation through type I electron transfer and type II energy transfer reactions. Our results show that open-cage C₆₀ fullerenes are more efficient for pho

SUBMITTER: Castanyer C 

PROVIDER: S-EPMC11713577 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature