Carbohydrate Deacetylase Unique to Gut Microbe Bacteroides Reveals Atypical Structure.

ABSTRACT: Bacteroides are often the most abundant, commensal species in the gut microbiome of industrialized human populations. One of the most commonly detected species is Bacteroides ovatus. It has been linked to benefits like the suppression of intestinal inflammation but is also correlated with some autoimmune disorders, for example irritable bowel disorder (IBD). Bacterial cell surface carbohydrates, like capsular polysaccharides (CPS), may play a role in modulating these varied host interactions. Recent studies have begun to explore the diversity of CPS loci in Bacteroides; however, there is still much unknown. Here, we present structural and functional characterization of a putative polysaccharide deacetylase from Bacteroides ovatus (BoPDA) encoded in a CPS

SUBMITTER: Schwartz LA 

PROVIDER: S-EPMC11713874 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature