Endothelial activating transcription factor 3 promotes angiogenesis and vascular repair in the mouse retina.

ABSTRACT: Ischemia and pathological angiogenesis in retinal vascular diseases cause serious vision-related problems. However, the transcriptional regulators of vascular repair remain unidentified. Thus, the factors and mechanisms involved in angiogenesis must be elucidated to develop approaches for restoring normal blood vessels. Here, we investigated the effects of the stress response activating transcription factor 3 (ATF3) on angiogenesis and vascular regeneration in vitro and in vivo. ATF3 was expressed specifically in retinal vascular endothelial cells (ECs) during vascular development. Vascular endothelial growth factor stimulation upregulated ATF3 expression in cultured ECs. The downregulated ATF3 expression in ECs caused the deterioration of vascular

SUBMITTER: Ueda C 

PROVIDER: S-EPMC11714383 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature