Nucleos(t)ide Analog Treatment Discontinuation in Chronic Hepatitis B Virus Infection: A Systematic Literature Review.

ABSTRACT:

Background and aims

The aim of this systematic literature review (SLR) was to examine outcomes and associated predictors following nucleos(t)ide analog (NA) treatment cessation in adult patients with chronic hepatitis B virus infection.

Methods

The SLR was conducted according to PRISMA methodology. All included studies were quality assessed using appropriate scales or checklists.

Results

The SLR identified 145 studies. Cumulative rates of clinical relapse (40 studies), virological relapse (53 studies), biochemical relapse (10 studies) and retreatment events (14 studies) post NA cessation varied widely across studies (clinical relapse: 40%-65%, virological relapse: 75%-94%, biochemical relapse: 63%-73%, retreatment rates: 30%-78% at 24 and 144 weeks, respectively). Sig

SUBMITTER: Gish R 

PROVIDER: S-EPMC11714690 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature