Age at ART initiation and proviral reservoir size in perinatal HIV-1 infection: considerations for ART-free remission.

ABSTRACT:

Purpose of review

Achieving ART-free remission without the need for lifelong antiretroviral treatment (ART) is a new objective in HIV-1 therapeutics. This review comprehensively examines the literature to evaluate whether the age at ART initiation in children with perinatal HIV-1 influences the size and decay of the HIV-1 reservoir. The insights gathered from this review serve to inform the field on the unique dynamics of HIV-1 reservoir size in perinatal HIV-1 infection as a function of age at ART initiation, as well as inform biomarker profiling and timing of ART-free remission strategies for children living with HIV-1 globally.

Recent findings

Recent studies demonstrate that initiating very early effective ART in neonates is feasible and limits HIV-1 reservoir size. The c

SUBMITTER: Bekka S 

PROVIDER: S-EPMC11715321 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature