Relationship between CTF1 gene expression and prognosis and tumor immune microenvironment in glioma.

ABSTRACT:

Objective

This study aimed to evaluate CTF1 expression in glioma, its relationship to patient prognosis and the tumor immune microenvironment, and effects on glioma phenotypes to identify a new therapeutic target for treating glioma precisely.

Methods

We initially assessed the expression of CTF1, a member of the IL-6 family, in glioma, using bioinformatics tools and publicly available databases. Furthermore, we examined the correlation between CTF1 expression and tumor prognosis, DNA methylation patterns, m6A-related genes, potential biological functions, the immune microenvironment, and genes associated with immune checkpoints. We also explored potential associations with drug sensitivity. To assess the impact on glioma cell proliferation and apoptosis, we employed various

SUBMITTER: Cai H 

PROVIDER: S-EPMC11715937 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature