Association of Ground-Glass Opacities with Systemic Inflammation and Progression of Emphysema.

ABSTRACT: Rationale: Ground-glass opacities (GGOs) in the absence of interstitial lung disease are understudied. Objectives: To assess the association of GGOs with white blood cells (WBCs) and progression of quantified chest computed tomography emphysema. Methods: We analyzed data of participants in the SPIROMICS study (Subpopulations and Intermediate Outcome Measures in COPD Study). Chest radiologists and pulmonologists labeled regions of the lung as GGOs, and the adaptive multiple feature method (AMFM) trained the computer to assign those labels to image voxels and quantify the volume of the lung with GGOs (%GGO_AMFM). We used multivariable linear regression, zero-inflated negative binomial, and proportional hazards regression models to assess the association of %GGO

SUBMITTER: Fortis S 

PROVIDER: S-EPMC11716031 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature