Highly efficient Ca²⁺ chelation activated by visible light.

ABSTRACT: Calcium ion (Ca²⁺) control is an essential tool in neuronal research. Herein, we report three thiocoumarin-based, visible light-activated Ca²⁺ chelators with quantum yields of 0.39, 0.52, and 0.83. The chelators demonstrated an over 10⁵-fold increase in Ca²⁺ binding affinity upon irradiation. These chelators are efficiently triggered by biologically safer wavelengths, rendering them excellent candidates for use in neurological research and medicine.

SUBMITTER: Egodawaththa NM 

PROVIDER: S-EPMC11717440 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature