Imaging the translocator protein 18 kDa within cognitive control and declarative memory circuits in virally suppressed people with HIV.

ABSTRACT:

Objectives

Virally suppressed people with HIV (VS-PWH) show heterogeneity in patterns of cognitive dysfunction. To better understand the relationship between the neuroimmune response and cognition, we used PET to image the translocator protein 18 kDa (TSPO). The study examined HIV-serostatus differences in TSPO as well as associations between regional TSPO and select cognitive processes defined using the Research Domain Criteria (RDoC) framework.

Design

Cross-sectional investigation in VS-PWH ( n  = 25) versus HIV-uninfected individuals ( n  = 18) of cognitive control and declarative memory, as well as [ 11 C]DPA-713 PET measures of TSPO within cognitive control and declarative memory regions of interest (ROI).

Methods

Group differences in [ 11 C]DPA-713 binding ( VT

SUBMITTER: Rubin LH 

PROVIDER: S-EPMC11717590 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature