Viral Determinants of Childhood Asthma Exacerbation Severity and Treatment Response.

ABSTRACT:

Background

Although respiratory viruses are common triggers of asthma exacerbations, the influence of viral infection characteristics on exacerbation presentation and treatment response in the pediatric emergency department (ED) is unclear.

Objective

To assess viral infection characteristics of children experiencing ED asthma exacerbations and to test their associations with severity and treatment response.

Methods

This is a prospective study of children, aged 4 to 18 years, who received standard ED asthma exacerbation treatment with inhaled bronchodilators and systemic corticosteroids. Nasal swabs collected for viral metagenomic analyses determined virus presence, load, and species. Outcomes included exacerbation severity (Pediatric Asthma Severity [PAS] score, clini

SUBMITTER: Navanandan N 

PROVIDER: S-EPMC11717597 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature