Hyaluronan provokes inflammation but suppresses phagocytotic function in macrophages.

ABSTRACT:

Background

The extracellular matrix (ECM) provides structural and functional support for the myocardium, but myocardial infarction (MI) changes the composition of the ECM. One of the chief components of the ECM, hyaluronan (HA), accumulates after MI; however, specific biological actions of HA-particularly at the level of infiltrating immune cells and implications of such interactions on ventricular remodeling-have not been explored.

Goal

Because acute accumulation of HA coincides with macrophage infiltration after MI, we assessed the impact of HA on macrophage function.

Results

Compared to SHAM hearts, HA levels were elevated in both the infarct and remote regions of infarcted hearts. Because acute accumulation of HA coincides with macrophage infiltration after MI, we

SUBMITTER: Audam TN 

PROVIDER: S-EPMC11717599 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature