Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity.

ABSTRACT: The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has bee

SUBMITTER: Cabrera-Alarcon JL 

PROVIDER: S-EPMC11718132 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature