Clinical epidemiology, genetic diversity, and drug susceptibility patterns by whole genome sequencing of Mycobacterium tuberculosis complex isolates in Gabon from 2012 to 2022.

ABSTRACT:

Objectives

This study aimed to investigate genotypic characteristics and drug resistance profiles of Mycobacterium tuberculosis complex (Mtbc) strains isolated from patients with suspected tuberculosis (TB) in Gabon.

Methods

We performed whole genome sequencing of 430 Mtbc strains cultured between 2012 and 2022. Phylogenetic strain classification, genomic resistance prediction, and cluster analysis were also performed.

Results

Strains from four major Mtbc lineages, L4 (n = 372; 65%), L5 (n = 46; 11%), L2 (n = 6; 1,4%), and L6 (n = 3; 0,7%), were observed. Interestingly, more than 10% of the strains were represented by Mycobacterium africanum strains (L5 and L6), with L4 strains being dominant. The subclassification of L4 strains showed that L4.6.2.2 (Cam

SUBMITTER: Adegbite BR 

PROVIDER: S-EPMC11718294 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature