Drug use and acute kidney injury: a Drug-Wide Association Study (DWAS) in Denmark and Sweden.

ABSTRACT:

Background

Knowledge of which medications may lead to acute kidney injury (AKI) is limited, relying mostly on spontaneous reporting in pharmacovigilance systems. We here conducted an exploratory drug-wide association study (DWAS) to screen for associations between dispensed drugs and AKI risk.

Methods

Using two large Danish and Swedish data linkages, we identified AKI hospitalizations occurring between April 1997 and December 2021 in Denmark and between March 2007 and December 2021 in Sweden. We used a case-time control design comparing drug dispensing in the 3 months prior to the AKI with earlier periods for the same patient. Odds ratios (ORs) for the association between each drug and AKI were estimated using conditional logistic regression and adjusting for the presence of

SUBMITTER: Bosi A 

PROVIDER: S-EPMC11719035 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature