Prostaglandin E₂ regulates senescence and post-senescence neoplastic escape in primary human keratinocytes.

ABSTRACT: Aging of the epidermis partially occurs as a consequence of epidermal cell senescence, a non-proliferative state in which cells remain metabolically active and acquire changes in their secretome. We previously reported that senescent normal human epidermal keratinocytes (NHEKs) have two opposite outcomes: either cell death by excess of autophagic activity or escape from senescence to give rise to post-senescence neoplastic emerging (PSNE) cells. In this study, we investigated the role of PTGS2, the inducible enzyme of the prostaglandin biosynthesis pathway, in the onset of NHEK senescence and in the switch from senescence to pre-transformation. We provide evidence that the PTGS2/PGE₂/EP4 pathway plays a critical role in NHEK senescence as well as in senescence escape. We show th

SUBMITTER: Srour E 

PROVIDER: S-EPMC11719115 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature