Impact of NAFLD-related SNPs on the carotid atherosclerosis development; a five-year prospective observational study.

ABSTRACT:

Background and aims

The prevalence of metabolic dysfunction associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), has become a significant public health concern with an increased atherosclerotic cardiovascular disease risk. This study investigates the impact of NAFLD-related single nucleotide polymorphisms (SNPs) on carotid atherosclerosis development in a Japanese population without diabetes, dyslipidemia, and hypertension.

Methods

The prospective observational study, part of the Kyushu and Okinawa Population Study (KOPS), included 945 participants (median age 55 [47, 63]) without carotid atherosclerosis, increased alcohol intake, diabetes, dyslipidemia, hypertension, or chronic hepatitis at baseline. NAFLD-related SNPs (

SUBMITTER: Ikezaki H 

PROVIDER: S-EPMC11719292 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature