S6K2 in Focus: Signaling Pathways, Post-Translational Modifications, and Computational Analysis.

ABSTRACT: S6 Kinase 2 (S6K2) is a key regulator of cellular signaling and is crucial for cell growth, proliferation, and survival. This review is divided into two parts: the first focuses on the complex network of upstream effectors, downstream modulators, and post-translational modifications (PTMs) that regulate S6K2 activity. We emphasize the dynamic nature of S6K2 regulation, highlighting its critical role in cellular homeostasis and its potential as a therapeutic target in diseases like cancer. The second part utilizes in silico analyses, employing computational tools to model S6K2's three-dimensional structure and predict its interaction networks. Molecular dynamics simulations and docking studies reveal potential binding sites and interactions with novel known inhibitors. We also examine the e

SUBMITTER: Khalil MI 

PROVIDER: S-EPMC11719502 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature