Evolutionarily Developed Alternatively Spliced Exons Containing Translation Initiation Sites.

ABSTRACT: Alternative splicing is essential for the generation of various protein isoforms that are involved in cell differentiation and tissue development. In addition to internal coding exons, alternative splicing affects the exons with translation initiation codons; however, little is known about these exons. Here, we performed a systematic classification of human alternative exons using coding information. The analysis showed that more than 5% of cassette exons contain translation initiation codons (alternatively skipped exons harboring a 5' untranslated region and coding region, 5UC-ASEs) although their skipping causes the deletion of translation initiation sites essential for protein synthesis. The splicing of 5UC-ASEs is under the repressive control of MATR3, a DNA/RNA-binding protein associa

SUBMITTER: Takeda JI 

PROVIDER: S-EPMC11719525 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature