Comparative Genomic Analysis Reveals Key Changes in the Genome of <i>Acremonium chrysogenum</i> That Occurred During Classical Strain Improvement for Production of Antibiotic Cephalosporin C.

ABSTRACT: From the 1950s to the present, the main tool for obtaining fungal industrial producers of secondary metabolites remains the so-called classical strain improvement (CSI) methods associated with multi-round random mutagenesis and screening for the level of target products. As a result of the application of such techniques, the yield of target secondary metabolites in high-yielding (HY) strains was increased hundreds of times compared to the wild-type (WT) parental strains. However, the events that occur at the molecular level during CSI programs are still unknown. In this paper, an attempt was made to identify characteristic changes at the genome level that occurred during CSI of the Acremonium chrysogenum WT strain (ATCC 11550) and led to the creation of the A. chrysogenum HY

SUBMITTER: Zhgun AA 

PROVIDER: S-EPMC11719821 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature