Associations Between Patient-Reported Nutritional Status, Toxicity, and Survival in Limited-Stage SCLC.

ABSTRACT:

Introduction

In general, malnutrition is associated with more treatment toxicity and shorter survival in patients with cancer, but little is known about its impact on limited-stage (LS) SCLC. We investigated whether nutritional status and weight loss were associated with treatment outcomes in a randomized trial of thoracic radiotherapy (TRT) in LS SCLC (NCT02041845, N = 170).

Methods

Patients received platinum-etoposide-chemotherapy and were randomized to receive TRT of 60 Gy in 40 fractions or 45 Gy in 30 fractions. They reported nutritional status on the Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) and were categorized as having low (PG-SGA SF score 0-3), intermediate (score 4-8), or high (score ≥ 9) malnutrition risk.

Results

In total, 113

SUBMITTER: Taranova E 

PROVIDER: S-EPMC11719838 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature