TP53I11 Functions Downstream of Multiple MicroRNAs to Increase ER Calcium Levels and Inhibits Cancer Cell Proliferation.

ABSTRACT: Cells meticulously regulate free calcium ion (Ca²⁺) concentrations, with the endoplasmic reticulum (ER) being crucial for Ca²⁺ homeostasis. Disruptions in ER Ca²⁺ balance can contribute to various diseases, including cancer. Although considerable research has focused on the direct mechanisms of ER Ca²⁺ regulation, the role of microRNAs (miRNAs) in this process remains underexplored. Mainly using data from a CRISPR-based genomic screening previously conducted in our laboratory, we identified 33 candidate miRNAs that may regulate ER Ca²⁺ levels. From these, 10 miRNAs were found to significantly lower basal ER Ca²⁺ levels. RNA sequencing analysis indicated that these miRNAs downregulate the tumor suppressor tumor protein p53 (T

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11719883 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature