Exploring the Link Between Obligate Anaerobe-Related Dysbiosis and Prostate Cancer Development: A Pilot Study.

ABSTRACT:

Background/objectives

Several independent studies have associated prostate cancer (PCa) with specific groups of bacteria, most of them reporting the presence of anaerobic or microaerophilic species such as Cutibacterium acnes (C. acnes). Such findings suggest a prostate cancer-related bacterial dysbiosis, in a manner similar to the association between Helicobacter pylori infection and gastric cancer. In an earlier exploratory study looking for such dysbiosis events, using a culturomics approach, we discovered that the presence of obligate anaerobes (OAs) along with C. acnes was associated with increased prostate-specific antigen (PSA) levels in 39 participants.

Methods

Building on this, in this study, we analyzed 89 post-rectal examination urine s

SUBMITTER: Ladoukakis E 

PROVIDER: S-EPMC11720123 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature