Secretome of the Olfactory Ensheathing Cells Influences the Behavior of Neural Stem Cells.

ABSTRACT: Olfactory ensheathing cell (OEC) transplantation demonstrates promising therapeutic results in neurological disorders, such as spinal cord injury. The emerging cell-free secretome therapy compensates for the limitations of cell transplantation, such as low cell survival rates. However, the therapeutic benefits of the human OEC secretome remain unclear. We harvested the secretome from human mucosal OECs and characterized its protein content, identifying 709 proteins in the human OEC secretome from three donors in two passages. Thirty-nine proteins, including neurological-related proteins, such as profilin-1, and antioxidants, such as peroxiredoxin-1 and glutathione S-transferase, were shared between the six samples. The secretome consistently demonstrated potential effects such as antioxida

SUBMITTER: Hsueh YH 

PROVIDER: S-EPMC11720278 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature