Association of antihypertensive drug target genes with alzheimer's disease: a mendelian randomization study.

ABSTRACT:

Background

Epidemiological and genetic studies have elucidated associations between antihypertensive medication and Alzheimer's disease (AD), with the directionality of these associations varying upon the specific class of antihypertensive agents.

Methods

Genetic instruments for the expression of antihypertensive drug target genes were identified using expression quantitative trait loci (eQTL) in blood, which are associated with systolic blood pressure (SBP). Exposure was derived from existing eQTL data in blood from the eQTLGen consortium and in the brain from the PsychENCODE and subsequently replicated in GTEx V8 and BrainMeta V2. We performed two-sample Mendelian randomization (MR) to estimate the potential effect of different antihypertensive drug classes on AD using sum

SUBMITTER: Zheng H 

PROVIDER: S-EPMC11720623 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature