Dengue Virus Infection: Immune Response and Therapeutic Targets.

ABSTRACT: Flavivirus infection, especially dengue virus infection caused by DENV, is known to be a significant health concern globally owing to the high incidence and mortality rate. The expanding and increasing disease burden calls for the need to develop an effective treatment and prevent the event of fatal complications, including dengue hemorrhagic fever/dengue shock syndrome. The DENV-induced immune response has been described as paradoxical because it has a protective role in viral clearance but, at the same time, causes more severe infection through viral-specific immunity. This is further complicated by high homology and cross-reactivity between different serotypes of DENV, causing a more severe disease presentation during secondary infection by a heterologous serotype. This serotype complex

SUBMITTER: Tin Ern N 

PROVIDER: S-EPMC11720763 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature