Novel Therapies to Reduce Rehospitalization Risk in Worsening Heart Failure: Systematic Review and Network Meta-Analysis.

ABSTRACT:

Background

Worsening heart failure (WHF) challenges health care with frequent rehospitalizations and reduced quality of life for patients. Despite therapeutic advances, high rehospitalization risks highlight the urgent need for new treatments.

Objectives

This study evaluated the effectiveness of initiating novel therapies during hospitalization or vulnerable phase for WHF patients to reduce rehospitalization risks and determine the optimal treatment sequence.

Methods

A systematic review and network meta-analysis were performed in accordance with Cochrane Collaboration and Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. We included randomized clinical trials from January 2013, to December 2022, sourced from PUBMED and EMBASE, comparing no

SUBMITTER: Lima IGCV 

PROVIDER: S-EPMC11720910 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature