ERBB3-related gene PBX1 is associated with prognosis in patients with HER2-positive breast cancer.

ABSTRACT:

Background

HER2-positive breast cancer (BC) is a subtype of breast cancer. Increased ERBB3 expression has been implicated as a potential cause of resistance to other HER-targeted therapies. Our study aimed to screen and validate prognostic markers associated with ERBB3 expression by bioinformatics and affecting the prognosis of HER2 staging.

Methods

Analyzing differences in ERBB3-related groups. ERBB3 expression-related differentially expressed genes (DEGs) were identified and intersected with survival status-related DEGs to obtain intersected genes. Three algorithms, LASSO, RandomForest and XGBoost were combined to identify the signature genes. we construct risk models and generate ROC curves for prediction. Furthermore, we delve into the immunological traits, correlations,

SUBMITTER: Mo S 

PROVIDER: S-EPMC11720925 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature