Juruaca virus taxonomy, tolerance and resistance to infection, and inflammatory response modulation in murine model.

ABSTRACT: Juruaça virus (JUAV), previously unclassified, was isolated from bats and administered to neonatal and adult BALB/c mice to investigate acute and chronic disease progression. In this study, we conducted genomic sequencing to achieve taxonomic classification and utilized these models to explore the inflammatory response and sickness behavior in both neonatal and adult mice. Neonates received a single intranasal instillation of infected brain homogenate (20 µL), whereas 31-day-old mice were given the same volume intranasally for three consecutive days. Control groups were administered equal volumes of uninfected brain homogenate. Our findings reveal that intranasal JUAV infection-induced acute meningoencephalitis and death in neonates, while adult mice exhibited chronic infection with variab

SUBMITTER: da Silva Cabral T 

PROVIDER: S-EPMC11721108 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature