In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae.

ABSTRACT: In the global effort to discover or design new effective antibiotics to fight infectious diseases, the increasingly available multi-omics data with novel bioinformatics tools open up new horizons for the exploration of the genetic potential of bacteria to synthesize bioactive secondary metabolites. Rare actinomycetes are a prolific source of structurally diverse secondary metabolites that exhibit remarkable clinical and industrial importance. Recently several excellent genome mining tools have been available for identifying biosynthetic gene clusters, however in cases of poor-quality sequences and inappropriate genome assembly, these tools are not always able to identify the corresponding gene clusters. In this context, based on the previously characterized primycin biosynthetic gene clust

SUBMITTER: Kovacs-Valasek M 

PROVIDER: S-EPMC11721240 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature