High-resolution multimodal profiling of human epileptic brain activity via explanted depth electrodes.

ABSTRACT: The availability and integration of electrophysiological and molecular data from the living brain is critical in understanding and diagnosing complex human disease. Intracranial stereo electroencephalography (SEEG) electrodes used for identifying the seizure focus in patients with epilepsy could enable the integration of such multimodal data. Here, we report multimodal profiling of epileptic brain activity via explanted depth electrodes (MoPEDE), a method that recovers extensive protein-coding transcripts, including cell type markers, DNA methylation, and short variant profiles from explanted SEEG electrodes matched with electrophysiological and radiological data allowing for high-resolution reconstructions of brain structure and function. We found gene expression gradients that correspond

SUBMITTER: Dwivedi AK 

PROVIDER: S-EPMC11721296 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature