Unveiling the critical roles of cellular metabolism suppression in antibiotic tolerance.

ABSTRACT: Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria, potentially acting as antagonists by inducing cell dormancy and promoting cell survival. However, the specific synergistic or antagonistic effects of these inhibitors depend on factors like their mechanisms of action, concentrations, and treatment timings, which require further investigation. In our study, we systematically explored the synergistic interactions of various metabolic inhibitors-such as chloramphenicol (a translation inhibitor), rifampicin (a transcription inhibitor), arsenate (an ATP production inhibitor), and thioridazine (a PMF inhibitor)-in combination with ofloxacin. We conducted this investigation under pre-, co-, and post-treatment conditions, employing a wide concentration ran

SUBMITTER: Mohiuddin SG 

PROVIDER: S-EPMC11721439 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature