Homeodomain Involvement in Nuclear HOX Protein Homo- and Heterodimerization.

ABSTRACT: HOX genes play essential roles in patterning the anteroposterior axis of animal embryos and in the formation of various organs. In mammals, there are 39 HOX genes organized into four clusters (HOXA-D) located on different chromosomes. In relationship with their orderly arrangement along the chromosomes, these genes show nested expression patterns which imply that embryonic territories co-express multiple HOX genes along the main body axis. Interactomic database entries, as well as a handful of publications, support that some HOX proteins can form homodimers or interact with other HOX proteins. However, the consequences of HOX protein interactions have been poorly investigated and remain largely elusive. In this study, we compiled a repository of all HOX-HOX interaction

SUBMITTER: Marchese D 

PROVIDER: S-EPMC11721573 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature